Endocrine Abstracts

Introduction: Aldosterone synthase participates in the key reactions of aldosterone synthesis – 11-hydroxylation, 18-hydroxylation and, finally, 18-oxidation. In recent works devoted to evaluating the effectiveness of hybrid steroids in the differential diagnosis of subtypes of primary aldosteronism (PA), it is worth emphasizing the experience of using high-performance liquid chromatography – tandem mass spectrometry (HPLC-MS/MS), which allows detecting even very low...

Objective: To determine the incidence of endometrium pathology in women with autoimmune thyroid pathology and history of reproductive losses, including an assessment of histological images and immunohistochemical (IHC) analysis of the endometrial receptor status.Materials and methods: A prospective cohort study included a clinical and instrumental examination of 84 women aged 18 to 45 years with a history of 1 to 3 consecutive pregnancy losses. Patients ...

Aldosterone-secreting adrenocortical carcinoma (ACC) is rare neoplasm, which detected in 2.5% of active ACCs.Clinical case: A 58 years old female, was admitted to our clinic with complaints of high blood pressure, back pain, weakness, convulsions. Biochemical evaluation confirmed primary hyperaldosteronism (serum aldosterone 1012 pg\ml, serum renin concentration 0.5 mkME\ml, aldosterone-renin ratio 202.4, hypokalemia 1.2 mmol\l). There was no evidence of...

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

Pregnant women are at risk of developing diseases associated with deficiency of essential micronutrients.Objective: To assess the prevalence of vitamin D deficiency among pregnant women and its dependence on the trimester of pregnancy.Methods: We examined 476 pregnant women at different gestational periods from three regions of Russia (Moscow, Ivanovo, Smolensk). Concentration of 25(OH)vitamin D (ng/ml) was estimated by immunometri...

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...

Diabetic foot syndrome (DFS) is currently considered the most severe of all late diabetes complications, resulting in deteriorating health outcomes, increased disability and reduced life expectancy.Aim: To study the frequency of occurrence of DFS in rural peoples with diabetes in Uzbekistan.Methods: Upon the international project WDF08-379 ‘Prevention of lower limb amputations in people with diabetes in Uzbekistan’, imple...

Of all the late complications of diabetes, foot lesions are the most preventable. The multidisciplinary approach to providing specialized help for people with diabetes can prevent the amputations in 49–85% diabetic foots.Aim: The organization of specialized help to patient with diabetic foot syndrome (DFS) by the establishing the network of ‘Diabetic foot’ rooms and training of multidisciplinary team of specialists (endocrinologist, surgeo...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, CPA ‘UMID’ jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diabetes mel...